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SGLT2is, and GLP-1 RAs in particular promote weight loss, and therefore especially may be of benefit, given that overweight and obesity is increasingly prevalent (62%) in individuals with type 1 diabetes [12]

And the difference between those two things determines whether you lose mostly fat, preserve your muscle, feel energized through the process, or end up exhausted, nutrient-depleted, and frustrated with side effects that never needed to happen

This could suggest a regulatory bottleneck at the level of Sphingosine conversion or degradation in these mutants

Changes in muscle function and sarcopenia Handgrip strength increased significantly both at M7 (+3.7 kg) and M12 (+4.1 kg) compared to baseline (Figure 2C)