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Cessation is consistently linked to rebound weight gain, and retrospective data suggest greater gestational weight gain and higher risks (e.g., preterm delivery, GDM, hypertensive disorders) after stoppingthough causality remains uncertain

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Dula also significantly reduced the expression of transforming growth factor-1 (TGF-1), phosphatidylinositol-3-kinase (PI3K), protein kinase B (AKT) signaling pathway, and the inflammatory cytokines: nuclear factor kappa B (NF-B), interleukin-6 (IL-6), and interferon- (IFN-) in colonic cellular structures