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Abstract Glucagon-like peptide-1 (GLP-1) is an incretin hormone released from gut enteroendocrine cells that modulates glucose metabolism by controlling insulin excretion and glucagon secretion and inhibits gastric emptying leading to decreased food intake, thus limiting weight gain

However, maintaining consistent dosing helps support the best long-term results

Practical tapers often hold each lower step for 8 to 12 weeks, although that schedule has not been tested directly