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Important Safety Information: Gastrointestinal Effects are the predominant side effects according to the prescribing information: Nausea (12-24% of patients) typically mild to moderate and often diminishes over time Diarrhea (13-17% of patients) usually transient and manageable with dietary modifications Vomiting (6-10% of patients) more common at higher doses Constipation (5-11% of patients) may require increased fluid intake and fiber Abdominal pain and dyspepsia (5-10% of patients) generally self-limiting Decreased appetite an expected pharmacological effect that contributes to weight loss These gastrointestinal symptoms are dose-dependent and typically most pronounced during the first few weeks after starting treatment or increasing the dose

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