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Diabetic patients have reported experiencing worsening blood sugar spikes and higher blood sugar levels than before they started taking the drug

There is some speculation among users on Reddit that glucagon receptor activation might help preserve muscle mass by increasing energy expenditure and promoting fat breakdown

Effects of sequential treatment with lixisenatide, insulin glargine, or their combination on meal-related glycaemic excursions, insulin and glucagon secretion, and gastric emptying in patients with type 2 diabetes
