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Description
Recent phase 2 studies of CagriSema, a once-weekly combination of cagrilintide (an amylin analogue) and semaglutide, and triple-hormone (GLP1, GIP, glucagon) receptor agonist, retatrutide, demonstrated an average 2%-2.2% reduction in HbA 1c at 24 weeks and a mean 16%-17% reduction in body weight (with the highest doses) at 32-36 weeks in those with obesity and T2D [70,71]
Tirzepatide, a dual GIP and GLP-1 receptor agonist, follows a similar pattern but uses different dose increments: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg
The maximum recommended maintenance dose is 3 mg once daily
Certain aspects of Saxenda treatment could theoretically contribute to throat symptoms in susceptible individuals
