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It is also important to realize that exercise comes with additional health and longevity benefits (additional healthy years, significantly reduced risk of many chronic diseases, improved mental health, etc.)

Application of heat or cold therapy to affected joints may provide symptomatic relief

While one might think adding a GLP-1 agonist would help, the primary effect of high-dose agonists is usually a further slowing of the upper GI tract

The food passage stimulates the release of gut hormones, and water shifts from the bloodstream into the intestines leading to bloating, diarrhea, hypotension, tachycardia, and reactive hypoglycemia due to the exaggerated release of insulin