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Description
Nausea is one of the most common side effects when starting semaglutide, affecting up to 25% of users in the first weeks
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Conclusions Hypomorphic PAM T2D-risk alleles reduce amidating enzyme activity, elevate circulating GLP-1 levels, and impair GLP-1 post-receptor signaling, culminating in a selective and clinically meaningful reduction in GLP-1RA efficacy
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