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The -helix of Ex4(9-39) is amphipathic (Figure 3B) and interacts with the NTD via residues on both faces, although it is the hydrophobic face which appears most important, with Val 19 , Phe 22 , Ile 23 and Leu 26 being buried in the binding site

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These include not only effects of weight loss, but also improvements in endothelial function, reductions in low-grade inflammation (evidenced by a significant decrease in high-sensitivity C-reactive protein levels), and potential plaque stabilization [73]