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Source: Employer Benefit Research Institute April 16, 2026 GLP-1 medications for obesity carry a well-documented discontinuation problem, and stopping them typically means regaining weight and the return of cardiometabolic risk factors

Many prescription weight loss medications cause gastrointestinal issues (nausea, diarrhea, constipation), or some rare but serious effects (pancreatitis, gallstones) may occur

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