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What they found was shocking: the risk of developing NAION, a condition that causes sudden, painless, and often permanent vision loss, was significantly higher in those using the drug

Konturek PC, Brzozowski T, Pajdo R, et al

If an experimental drug reduces disease progression and results in less need to change symptomatic medications, an imbalance in medication changes between groups can potentially mask or underestimate the true benefits of the new therapy 8

Quantitative outputs from in vitro experiments allow construction of predictive molecular networks , supporting hypothesis-driven analysis of signal propagation and regulatory feedback mechanisms
