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The generalizability issues with STEP 5 mirror those of the other STEP trials notably, the structured weight management regime that patients followed in the trial, which is unlikely to be available to patients in most areas of Canada
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They concluded in the pooled analysis of 5,325 randomized and exposed individuals that rates of depression (2.1 vs 2.1 events/100 person-years) through adverse event reporting were similarly low in liraglutide and placebo groups
