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Quick Answer: There is no established direct link between Zepbound (tirzepatide) and decreased libido in FDA prescribing information or clinical trial data

Finally, we noted a significant increase in the AP firing frequency in response to GLP-1 (from 3.00.5 to 4.90.5 Hz, n =32, P =0.0004, paired t test) (Supplemental Fig

This dual action may explain why some patients report more significant headache improvement on tirzepatide compared to single-target GLP-1 medications