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However, none of the studies identified in this systematic literature review used rewards other than food for GLP-1

Though metformin is not FDA-approved for weight loss in non-diabetic

What were learning is that their effects may not be limited to the stomach and digestive system. Because the medications affect pathways involved in appetite, glucose metabolism, and inflammation, researchers are studying whether they may also influence certain functions within the brain

Current evidence suggests that most patients who tolerate treatment during the first year continue to do well later
