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While taste changes during treatment with GLP-1 receptor agonists or dual GIP/GLP-1 receptor agonists are generally benign and self-limiting, certain situations warrant medical evaluation to rule out complications or alternative diagnoses

Growth hormone stimulates proteinsynthesis and inhibits muscle breakdown, which is particularly relevant whenthe body is losing weight and might otherwise catabolize lean tissue forenergy

This broader mechanism may help explain why retatrutide has shown strong results in clinical trials

The macrophage shift is one reason why GLP-1 receptor agonists show benefit across such diverse autoimmune conditions