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GLP-1 Reduces appetite, slows gastric emptying GIP Enhances insulin, improves fat metabolism Glucagon Increases energy expenditure, burns fat Based on Phase 2 clinical trial data (published in NEJM, 2023), retatrutide's side effects are primarily gastrointestinal, similar to other GLP-1 agonists but with some differences due to the glucagon component

You may need to take a period of time between stopping one medication and starting another to make sure the medications do not overlap and reduce side effects during the adjustment period

This hyperarousal usually resolves within 2 to 4 weeks as your system acclimates

Besides Kentucky, other Southeastern states with high rates of GLP-1 use include Alabama (1.7%), West Virginia (1.7%), and Georgia (1.6%)