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And in numerous monogenic diseases, many different mutations to that gene can each lead to the same disease

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Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: A randomized phase 2a trial

Clinical trial data shows discontinuation rates of 4-7% due to GI side effects for semaglutide, and slightly higher (6-9%) for tirzepatide, likely because higher doses are used
