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Extensive preclinical studies have shown that incretin-based drugs can achieve significant cerebral protection and reduce neuronal loss by reducing synaptic loss and amyloid plaque load, decreasing hyperphosphorylation of proteins, and anti-inflammatory effects [54]

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Consideration of sick day management, patient education, the adjustment of glucose-lowering medications as the eGFR declines and screening for other microvascular diabetes-related complications (e.g

Triggers for initiating a discussion on switching may include HbA 1c targets not being met, the need for additional weight loss, patients moving to an increased cardiovascular risk status and poor adherence