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Additionally, assessment and control of other risk factors (e.g., sleep apnea) may be considered prior to or concurrent with initiation of semaglutide or tirzepatide treatment, Krauss added.

Anti-inflammatory and anti-fibrotic mechanisms Although retatrutide treatment resulted in pronounced weight loss, prior studies have shown that obesity-associated immune, metabolic, and fibrotic signatures in epididymal adipose tissue can persist despite substantial weight loss, indicating that adipose tissue remodeling cannot be fully explained by weight loss [38, 39]

Pancreatitis, though rare, represents a serious potential adverse effect of GLP-1 receptor agonists

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