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Mechanism: Prescription GLP-1 receptor agonists (semaglutide, tirzepatide) directly bind to GLP-1 receptors at pharmaceutical concentrations, producing measurable hormone-level effects on appetite, gastric emptying, and insulin secretion

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Nine SAEs were in participants in the placebo group and two SAEs and one SUSAR were in the semaglutide group

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The FDA warns that compounded or research-only GLP-1 products may be unsafe or dosed incorrectly and havent been reviewed for quality or effectiveness

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While GLP-1s are not known to cause depression (in fact, some people feel happier as they lose weight), your provider might still check in on how youre feeling emotionally

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