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As postprandial hyperglycemia was observed in intestinal epithelial cell-specific Sirt1 KO mice, SIRTs could be the molecule connecting intestinal NAMPT-mediated NAD + biosynthesis and canonical Wnt signaling to stimulate GLP-1 secretion [31,94] (Figure 2 and Figure 3)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 68.Chen S.-Y., Kong X.-Q., Zhang K.-F., Luo S., Wang F., Zhang J.-J

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