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In the STEP 1 trial published in Diabetes, Obesity, and Metabolism , participants who paired weekly semaglutide for weight loss with a structured lifestyle intervention regained an average of two-thirds of the weight theyd lost within one year after stopping both

Others find they no longer need the same level of appetite suppression that helped them lose weight in the first place

Persistent or unexplained stool colour changes warrant prompt GP evaluation to exclude serious pathology

[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Tsermpini E.E., Goriar K., Kores Plesniar B., Plemenita Ilje A., Dolan V
