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In an additional, 30-week placebo-controlled, study of patients with type 2 diabetes inadequately controlled with metformin comparing the maintenance of sitagliptin 100 mg versus withdrawal of sitagliptin when initiating basal insulin therapy, the event rate and incidence of documented symptomatic hypoglycemia (blood glucose measurement 70 mg/dL) did not differ between the sitagliptin and placebo groups

Luna-Marco C, de Maraon AM, Hermo-Argibay A, et al

And because both obesity and diabetes are chronic conditions, stopping the medication often reverses the gains, sending weight and blood sugar creeping back

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