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These inconsistencies may be due to the small sample size of the included studies, differences in baseline characteristics of study participants, differences in study design such as follow-up duration or control group, and other factors

They've actually been around for quite a while in that capacity, but subsequent trials showed that, "Hey, these medications have substantial weight loss benefits, too." And so, now some are approved specifically for chronic weight management

2013;369:145-154) found that intensive lifestyle intervention focused on weight loss did not reduce cardiovascular events in a large cohort of adults with overweight/obesity and type 2 diabetes

(13) A key mechanism through which GLP-1 receptor agonists may influence bone metabolism is the osteoprotegerin (OPG)/RANKL/RANK pathway, which regulates osteoclast differentiation and bone resorption