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About Semaglutide One kind of GLP-1, semaglutide, was originally formulated to help those with type 2 diabetes gain better control over fluctuating blood sugar levels

Phase 3 clinical trials of Wegovy, known as the STEP (Semaglutide Treatment Effect in People with Obesity) trials, evaluated the medication across multiple patient populations

Han SH, Safeek R, Ockerman K, et al

Briefly, while the extracellular domain (ECD) of GLP-1R, which is responsible for ligand recognition and specificity, engages the C-terminus of the GLP-1, the interhelical transmembrane crevice of the GLP-1R helps in docking of the N-terminus of the GLP-1, triggering downstream signaling ( FIGURE 2 However, the naturally secreted GLP-1 is quickly hydrolyzed and rendered inactive by dipeptidyl peptidase-4 (DPP-4), a transmembrane amino peptidase