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With more structural and dynamics studies on class B GPCRs, the activation process from inactive to active states via an intermediate state, i.e., allosteric communication between extracellular peptide binding and intracellular G protein coupling, will be better understood

A patient may be a candidate for GLP-1 weight loss if they have obesity, overweight with weight-related health concerns, insulin resistance, prediabetes, type 2 diabetes risk, high blood pressure, high cholesterol, fatty liver concerns, sleep apnea risk, or repeated difficulty losing and maintaining weight with lifestyle changes alone

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