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In contrast, Gipr / mice exhibit greater resistance to diet-induced obesity, relative to Glp1r / mice (4)
obesity rate remains very high by historical standards

Despite these large structural differences, the TMD pocket volume of the GLP-1RFab7F38 structure (893 3 ) is of similar scale as the ligand-occupied GLP-1R pockets (5VAI: 1036 3

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