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[234] Statins have shown potential benefits on liver function tests in patients with MAFLD [235, 236], but their efficacy on steatosis or fibrosis is uncertain

Retatrutide then showed up with an even broader design and even bigger top-line weight-loss numbers

Despite their similarities, Semaglutide is available in two different doses and is given once a week while Tirzepatide is given once a week with the dosing options of 5 mg, 10 mg, 15 mg and 20 mg

In a recently published phase II study conducted on 92 T2D patients with a BMI 27 kg/m 2 , a 2.18% decrease in HbA1c and a 15.6% reduction in body weight were confirmed in the group administered CagriSema once a week [102]