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Wang et al., 2022)
The deficit of insulin also causes a reduction of glucokinase enzyme in the liver and the GLUT-4 transporter protein in adipose tissue resulting in an inability of the target tissues to respond normally to insulin
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doi: 10.1111/j.1399-5448.2011.00846.x 108 ZeitlerPHirstKCopelandKCEl GhormliLLevitt KatzLLevitskyLLet al
