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Description
Constrictive pericarditis from radiation has a particularly poor prognosis given often concurrent myocardial involvement
It demonstrates that the GLP-1 receptor's activation pathway is "convergent" rather than "pathway-specific": multiple distinct binding events at the extracellular surface can trigger the same conformational rearrangement at the intracellular surface
By binding to GLP-1 receptors, they provide a much stronger and longer-lasting signal than the natural hormone
Cells were equilibrated for 520 minutes, and then 20 L of 10 ligand was added and a luminescence time course was collected
