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Tirzepatide carries a boxed warning for thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

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Additionally, double KO of GPR40 and GPR120 more effectively eliminated the GIP response to the oral administration of corn oil compared to single KO of either receptor in murine models [54, 56], suggesting that both GPR40 and GPR120 are important in fat-stimulated GIP secretion [29]