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Through these mechanisms, GLP-1RAs promote protein clearance and reduce cellular stress that drives aggregation (Figure 1)

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Mol Metab 18:314 Holst JJ, Wewer Albrechtsen NJ, Pedersen J, Knop FK (2017) Glucagon and amino acids are linked in a mutual feedback cycle: the liver--cell axis

Dietary modifications are often the most effective first-line approach: Eat smaller, more frequent meals rather than large portions, as this reduces the burden on delayed gastric emptying Avoid high-fat foods , which are slower to digest and may exacerbate feelings of fullness and discomfort Reduce intake of spicy, acidic, or heavily seasoned foods that may irritate the gastrointestinal tract Limit carbonated beverages , which can increase bloating and abdominal distension Eat slowly and chew thoroughly to aid digestion and reduce the volume of air swallowed Stay well hydrated , particularly if experiencing diarrhoea, but avoid drinking large volumes with meals Timing considerations can also help