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Conclusion The disappointing outcome of Novo Nordisks semaglutide trials in Alzheimers disease highlights the limitations of current strategies based on the amyloid hypothesis

Flow chart of cryo-EM data processing of the hGLP-1rGLP-1RG s complex, including particle projection selection, classification and 3D density map reconstruction, related to Fig

However, potential side effects of branded GLP-1s are well-documented and must be disclosed according to FDA regulations

This limitation emphasizes the importance of employing diverse experimental models to enhance our understanding of Semas therapeutic implications in a broader, more clinically relevant context