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Glp1r Lck/ mice retain normal Glp1r levels in spleen and PBMCs (34), whereas mice with GLP-1R deletion in the Tie2 expression domain ( Glp1r Tie2/ ) show complete loss of Glp1r in these compartments (29), suggesting expression in nonT cell hematopoietic or endothelial cells

Tirzepatide (weekly) is a dual GIP/GLP-1 agonist with potentially greater results

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Poor sleep can reduce some of the benefits of GLP-1
