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Because GLP-1R agonists primarily act in the brain to suppress appetite, identifying stage-specific neural activity patterns is a key next step

In a patient with baseline heart rate 60 beats/min and stable blood pressure (systolic 110 mm Hg, diastolic 70 mm Hg), how should retatrutide and nebivolol be initiated together, including initial dosing, titration, monitoring for bradycardia and hypotension, and management of any adverse effects?

If it persists beyond 10 weeks, contact your provider about electrolyte support or dose adjustment

If the appointment is taking place in-person, patients may be able to receive their first dose at the initial consultation