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There was no difference in severe hypoglycaemia, genital candidiasis, acute pancreatitis, or gastrointestinal upset (nausea, vomiting and diarrhoea) between the two groups

Weight Loss without Harsh Side Effects Standard doses of GLP-1 RAs (Receptor Agonists) can result in rapid weight loss but often come with unpleasant side effects like nausea or vomiting

If Eli Lilly prices orforglipron below current injectable GLP-1 medications, cost becomes a factor favoring the oral option

DPP-4 inhibitors, GLP-1 receptor agonists, and SGLT-2 inhibitors are included as options for combination therapy with metformin for patients who require dual therapy to meet glycemic goals