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Abbreviations DM2: diabetes mellitus type 2 GCR: glucagon receptor GIPR: glucose-dependent insulinotropic peptide receptor GLP-1a: glucagon-like peptide-1 analogues HbA1c: glycated hemoglobin HCC: hepatocellular carcinoma MRI-PDFF: Magnetic Resonance Imaging-Proton Density Fat Fraction NAFLD: Non-alcoholic fatty liver disease NASH: non-alcoholic steatohepatitis NCT: National Clinical Trial number PPAR: Peroxisome Proliferator-Activated Receptor RCT: randomized clinical trial SGLT-2i: sodium-glucose co-transporter-2 inhibitors Declarations Funding None to declare

The drugs could produce huge benefits for people with obesity but also present a major cost challenge given the large percentage of the population that is eligible for them, the report said

24: The FDA has denied Theratechnologies supplemental Biologics License Application for an F8 formulation of tesamorelin, which is intended to reduce excess abdominal fat in patients with HIV and lipodystrophy

Intraperitoneal glucose tolerance test (IGTT) IGTT was performed after 20 days of hormone/vehicle treatment