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Hence, there is a continuous need for drugs that are innovative and efficacious like GLP-1 analogues, which have shown superior clinical outcomes and cardiovascular benefits as compared to traditional antidiabetic agents

Horm Metab Res 36:755760 [DOI] [PubMed] [Google Scholar] Chu ZL, Carroll C, Alfonso J, Gutierrez V, He H, Lucman A, Pedraza M, Mondala H, Gao H, Bagnol D, Chen R, Jones RM, Behan DP, Leonard J 2008 A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release

Under normal conditions, acute administration of liraglutide did not alter cecal occludin and TNF- mRNA levels, but significantly increased cecal RegIII and IL-33 mRNA levels (Fig