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Prescribing restrictions are likely to relax over time, and coverage and penetration improve, as increased competition and the entry of generics drive price erosion

Role of intra-islet paracrine signaling in the effects of pharmaceutical targeting of GLP-1 As current therapies focusing on increasing insulin sensitivity and/or insulin secretion fail to cure diabetes, one potentially underappreciated target for diabetes treatment is the alpha-cell

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140 Due to metformin and furosemides wide therapeutic index, the risk of clinically significant DDIs is low
