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If clinical markers are not improving after an adequate trial period at therapeutic doses, the prescribing clinician should reassess the treatment plan and consider whether retatrutide remains the most appropriate option
Klein notes that these tips may also help mitigate weight regain after stopping GLP-1 treatment

The future of weight-loss medicine will likely focus less on how fast can someone lose weight? and more on: How much fat was lost

However, there is limited evidence supporting this approach as a standard practice
