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These cytosine- and guanine-rich regions are prone to epigenetic modification like methylation, and thus inactivate or activate transcription of certain genes

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Several SURMOUNT studies in patients with obesity are ongoing ( In the SURPASS-1 study, which enrolled 705 non-target T2DM patients with diet and physical activity intervention, the efficacy, safety, and tolerability of tirzepatide and a placebo were compared