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Last week, the US Federal Trade Commission, a consumer watchdog agency, offered one answer, announcing a lawsuit against three of the biggest pharmacy benefit managers, or PBMs, companies that negotiate between insurance companies and drug manufacturers

Patients frequently report sustained appetite control, reduced food cravings, and improved energy levels within 2-4 weeks of starting therapy

Lifestyle screen: sleep, shift work, alcohol, prior diet attempts, resistance training or injuries limiting exercise

Real-world reports show wide variability: some observational analyses note that about 5% experience sleep disturbances, while a 2025 Care Pharmacy summary found that roughly 30% of patients on Wegovy reported insomnia