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The National Institute for Health and Care Excellence (NICE) recommends GLP-1 receptor agonists like Ozempic for patients who require additional glucose-lowering therapy when further treatment intensification is needed, particularly where weight loss would be beneficial

The geometric mean C max of semaglutide was 28.4 nmol/L

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H-Gln(Trt)-Ala-Ala-Lys(C18diacidmono-t-butyl-Glu-AEEA-AEEA)-OtBu)-Glu(OtBu)- Phe-Ile-Ala-Trp(Boc)-Leu-Val-Arg(Pbf)-Gly-Arg(Pbf)-Gly-OtBu H-Ser(tBu)-Tyr(tBu)-Leu-Glu(OtBu)-Gly-Gln(Trt)-Ala-Ala-Lys(C18diacidmono-t-butyl-Glu-AEEA-AEEA)-OtBul)- Glu (OtBu)-Phe-Ile-Ala-Trp(Boc)-Leu-Val-Arg(pbf)-Gly-Arg (pbf)-Gly-OtBu Boc-His(Trt)-Aib-Glu(OtBu)-Gly-Thr(tBu)-Phe-Thr(tBu)-Ser(tBu)-Asp (OtBu)-Val-Ser(Oxa)-Ser(tBu)-Tyr(tBu)-Leu- Glu(OtBu)-Gly-Gln(Trt)-Ala-Ala-Lys(C18diacid-Glu-AEEA-AEEA)-Glu (OtBu)-Phe-Ile-Ala-Trp(Boc)-Leu-Val-Arg(pbf)- Gly-Arg (pbf)-Gly-OtBu (Protected Semaglutide) (Crude Semaglutide) Pure Semaglutide Scheme-II The present invention provides a hybrid approach for the preparation of Semaglutide compound of formula-I