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The discontinuation rate is notably higher

Diabetes Obes Metab 20:22382245 Reigner BG, Williams PE, Patel IH, Steimer JL, Peck C, Van Brummelen P (1997) An evaluation of the integration of pharmacokinetic and pharmacodynamic principles in clinical drug development

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Its important to remember that the benefits of B-12 injections may vary depending on individual circumstances and existing B-12 levels
