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Repeated cycles of initiation, interruption and re-initiation of these drugs might induce body weight and HbA 1c fluctuations two risk factors for cardiovascular and microvascular events

Keywords: obesity, metformin, ozempic, liraglutide, diabetes mellitus, alzheimers, neurodegenerative disease, multiple sclerosis, glucagon-like peptide-1 agonists Introduction and background Multiple sclerosis (MS) is a chronic, progressive autoimmune disease affecting the central nervous system (CNS)

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25 Both affinity and activity reduce 10-fold if the Arg 36 of GLP-1 is cut away, 41 showing that it is crucial for interaction