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Given that potentially dangerous islet cell hyperplasia is reported to occur in some T2DM patients treated with GLP-1R agonists, 79 it might be possible to design allosteric modulators of the GLP-1R that preferentially stimulate insulin secretion rather than islet growth

These findings, together with the convenience of oncedaily oral dosing and onceweekly injection, support the use of these medications in this prediabetic population. Karen Elkind-Hirsch Elkind-Hirsch and colleagues recruited 119 premenopausal women aged 18 to 45 years with obesity and PCOS and without diabetes to participate in the study

Semaglutide, also known by the brand names Wegovy and Ozempic, is a glucagon-like peptide-1 (GLP-1) receptor agonist used to lower blood sugar levels, weight loss, and to lower the risk of heart attack, stroke, or death in patients with type 2 diabetes, obesity, and heart disease