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This shows up across care settings, especially during the first 6 to 12 weeks of starting treatment, so strategies that reduce haste, financial friction, or decision overload tend to improve tolerance

In England, this would be uncommon as, at time of publishing, NHS England allows the medication to be prescribed in primary care under a funding variation 6 for people with the following: Initial BMI 35 kg/m 2 (as of June 2026) and at least four of the following long-term conditions: Hypertension Dyslipidaemia Established cardiovascular disease Obstructive sleep apnoea (Type 2 diabetes) HSC obesity services are expected to commence in Northern Ireland in autumn 2026