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Description
Important contraindications include uncontrolled hypertension, a history of seizure disorders, and current or recent use of opioid medicines

With that said, their rapid rise in use has prompted increased scrutiny, and their status is an area to monitor as scientific understanding and usage patterns continue to evolve.

doi: 10.1172/JCI57256 [DOI] [PMC free article] [PubMed] [Google Scholar] 225

Triglycerides deserve particular attention in this discussion
