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Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met + SU): a randomised controlled trial

Although this observation cannot, in itself, unequivocally show that semaglutide causes delayed gastric emptying, it gives, in our view, reason for a significant safety concern, especially since it is consistent with the known mechanism of action of the drug

3 The most frequently reported adverse events were nausea, diarrhea, vomiting, constipation, abdominal pain, headache and fatigue

If a patient tolerates and benefits from one medication, adding a drug with a different mechanism preserves those benefits while enhancing overall effectiveness