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Description
Tirzepatide Research on naturally occurring incretins isolated from some fish (e.g., lamprey, dogfish and paddlefish) has shown that they can act as dual agonist of the GLP-1, GIP, and glucagon receptors, to lower blood glucose levels and induce weight loss (reviewed in Conlon et al., 2022)
Lancet Diabetes Endocrinol 10(3):193206
12 Replacement of GLP-1 His 7 with Phe 7 does not influence either its receptor affinity or cAMP activity, indicating that the aromaticity of His is crucial to its activity
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